DAN Lydiate is set to miss the rest of the season after rupturing knee ligaments on his Wales return.

The former Dragons favourite earned a Test recall thanks to his superb form for the Ospreys.

The 33-year-old earned his 65th cap against Ireland in the Six Nations opener and made a typically physical start until he then suffered an anterior cruciate ligament injury at the weekend.

Lydiate is facing a series of assessments and consultations to assess the extent of the problem.

"Well what can I say? Been over two years since I have had the opportunity to be involved with Wales," tweeted the flanker.

"Always a massive honour and a privilege to pull on the famous red jersey, even though it was short-lived. Wishing boys best of luck for the rest of the Six Nations."

Lydiate played his first Test since 2018, getting the nod ahead of Josh Navidi and Aaron Wainwright.

"We watched him a lot over the Christmas period and he's been the in-form six in Wales," said Wales defence coach Gethin Jenkins.

"To see that happen so innocently, the first thing you do is look at the clock and it's probably 10 minutes gone and you knew he was going off.

"I was gutted for him, obviously I have played with him, and you hope he gets well soon. It's a tough pill to swallow for him and for us as a squad."

Wales got off to a winning start after edging out Ireland 21-16 but head to Scotland with a patched-up side.

Scrum-half Tomos Williams has been ruled out with a hamstring injury.

"He has had a scan and it's not a simple one," said Jenkins. "He is probably going to be ruled out for a few games and we'll go from there."

Centre Johnny Williams and winger Hallam Amos are both sidelined with head injuries.

Pivac, who endured a miserable first year in the job, admitted the first major victory of his reign was tempered by a series of injury problems which left him "counting the walking wounded".

Wales say player call-ups will be made and announced in due course following Covid-19 testing and results.

It is hoped that George North will be fit to face Scotland after he scratched an eye during the second half on Sunday.

But Scarlets centre Jonathan Davies will again be missing at Murrayfield as he continues to nurse an ankle injury and Dragons centre Nick Tompkins is struggling with a shoulder injury.

With wing Josh Adams serving the second game of a two-match suspension for breaching Covid regulations, Liam Williams is set to go straight back into the XV to replace Amos.

The Lions speedster missed the opener after being sent off for a reckless clear out at a ruck for the Scarlets against Cardiff Blues.

Jenkins is confident that Williams will hit the ground running.

"He (Liam) has been training with us for two weeks," added Jenkins.

"Unfortunately Hallam has been ruled out so Liam becomes available for this weekend. He's served his ban and if he's selected, he'll be ready to go.'

Second-half tries from North and tournament debutant Louis Rees-Zammit, plus 11 points from the boot of Leigh Halfpenny, saw the hosts capitalise on Peter O'Mahony's early dismissal.