Cwmavon Road remains closed in both directions between the Shop Road junction and the Capel Newydd Avenue junction.
A Welsh Ambulance Service spokeswoman said: "We were called at 4.24pm today to reports of a road traffic collision on the A4043 between Cwmavon and Blaenavon.
"Two rapid response vehicles, two emergency ambulances and a BASICS doctor attended, and two people were taken to Nevill Hall Hospital in Abergavenny."
CWMAVON Road in Blaenavon is shut both ways following an accident.
A Gwent Police spokesman said the incident, which involved three vehicles, was reported at 4.18pm. Police remain at the scene.